Altamira Therapeutics to Participate in the 4th Annual RAS-Targeted Drug Development Summit
Sep 8th, 2022 7:17 EST
HAMILTON, BERMUDA , Sept. 08, 2022 (GLOBE NEWSWIRE) --
- Company’s Chief Scientific Officer Samuel Wickline, MD, to present on the Company’s innovative and patented OligoPhoreTM platform for the treatment of KRAS-driven cancers
- Forum will provide Altamira the opportunity to network with community of KRAS specialists hundreds of scientists from around the globe committed to targeting RAS-mutant cancers -- to develop potential strategic relationships.
Altamira Therapeutics ("Altamira" or the "Company") (NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced that it will participate in-person at the 4th Annual RAS-Targeted Drug Development Summit being held on September 26-28, 2022 in Boston, Massachusetts.
The Company currently has two RNA-based development programs utilizing its patented OligoPhore delivery platform and proprietary siRNA formulated to target KRAS and NF-κB signaling pathways. The first is the AM-401 program, which targets KRAS-driven cancers that commonly affect the pancreas, lungs, or colorectum. The second is AM-411 for the treatment for rheumatoid arthritis.
Altamira’s Chief Scientific Officer, Samuel A. Wickline, MD, will be presenting on the topic titled, “Extrahepatic Nucleotide Delivery with Self-Assembling Peptide-Based Nanostructures for RNAi against KRAS” and discuss the Company’s approach to treating KRAS-driven cancers and the key advantages of its OligoPhore delivery platform for targeting KRAS. Dr. Wickline will address the following aspects of siRNA therapeutics that differentiate the Company’s technology:
- Formulation of therapeutic polyplexes by noncovalent self-assembly with any type of single or multiplexed RNAs that are stable and safe in circulation
- Avoidance of hepatic uptake after systemic injection allowing accelerated permeation into tumor microenvironments and direct uptake by cancer cells
- Rapid and extensive pH-dependent release of RNA from endosomal compartments resulting in early and potent control of pathological protein expression
Altamira aims to become a leading provider of facile peptide-based polyplex technologies for extrahepatic RNA delivery. It actively seeks opportunities to out-license its AM-401 and AM-411 nanoparticle technologies as well as its OligoPhore (siRNA) and SemaPhore (mRNA) delivery platforms to other biopharmaceutical companies.
“We are looking forward to participating in this premiere scientific event and introducing our OligoPhore platform for the first time to a large community of KRAS specialists in cancer research and development,” said Thomas Meyer, Altamira Therapeutics' founder, Chairman and CEO. “We are seeing great potential for AM-401 in the targeted treatment of KRAS-driven cancers, which are amongst the most aggressive and lethal tumors known. The ability to deliver RNA therapeutics specifically to tumor cells opens up exciting opportunities for effective and safe new treatments in oncology.”
About the 4th Annual RAS-Targeted Drug Development SummitThe 4th RAS-Targeted Drug Development Summit is the only industry-focused wholly dedicated forum for the global community of individuals committed to targeting RAS-mutant cancers. This three-day event will be uniting 300+ experts to showcase exclusive novel data, optimizing translation and pre-clinical development to advance the landscape of clinical trials for combinations and monotherapies. With mounting success in targeted RAS drugs, leading frontiers and experts must unite and continue accelerating the applications of these therapeutics for patients in need. Through novel data, expert insight, and exclusive discussions with global leaders, the industry will facilitate vital learnings to progress RAS therapeutics to drug all mutations, continuing to advance valuable combination therapies into the clinic and, finally, crack resistance to RAS targeted therapeutics.
About OligoPhoreOligoPhore is a versatile platform for safe and effective delivery of oligonucleotides such as siRNA (small interfering ribonucleic acid) into target cells. It is based on a proprietary 21-amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has size, charge, and other physical features that allow it to escape hepatic uptake and thus to reach extrahepatic tissues. OligoPhore protects the RNA payload from degradation in the circulation and allows for rapid cellular uptake, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Effective delivery and positive treatment outcomes have been demonstrated in more than 10 murine models of disease for targets in the RAS and NF-κB families, the ETS transcription factor family, and targets in the JNK, TAM, and other signaling pathways.
About Altamira Therapeutics Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne allergens and, where approved, viruses (Bentrio™; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/
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